This issue can be caused by several factors which include the corrupt installation of Microsoft Excel, Excel startup preferences, etc. Though the issue sounds critical, it really is not. The issue can be easily resolved by implementing some easy fixes that are mentioned in the article down below. However, before we get into that, let us have a look at what potentially causes the issue.

What causes Microsoft Excel 2016 to open Blank on Windows 10?

Well, the issue can be caused by several things. In the list below, we have pointed out the ones that are most often responsible for generating the issue. Now that you have the basic insight of the potential factors that cause the issue, we can proceed to solve the issue. To solve the issue, please follow the solutions provided down below in the same order as given so that you get a hasty resolution.

Solution 1: Disable Hardware Acceleration

In some cases, the excel file appears blank because Microsoft Excel is not able to load the data of the file due to hardware acceleration for the graphics card. In such cases, you can fix the issue by disabling hardware acceleration. Here’s how:

Solution 2: Disable ‘Ignore DDE’ Option

Sometimes, the issue occurs when your Microsoft Excel has the DDE or also known as Dynamic Data Exchange enabled. This option lets other applications on your system subscribe to the items of Microsoft Excel. To fix this, you will have to make sure that the ‘Ignore DDE’ option is unchecked in Microsoft Excel. Here’s how:

Solution 3: Emptying XLSTART Folder

As we have mentioned above, your Microsoft Excel startup preferences can sometimes be the cause of the issue. Your startup preferences are stored in the XLSTART folder. Emptying this folder will reset the preferences and potentially fix your issue. Here’s how to locate the folder:

Solution 4: Repairing Microsoft Excel

If the above-mentioned solutions don’t fix your issue, then this means you have a corrupt Microsoft Excel installation. In such a case, you will have to repair the installation. This can be easily done by following the steps given down below: If none of the above methods work, make sure that you check that the document you are trying to open is indeed valid and readily available. If the document is moved or deleted, it will not accessible.

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