A lot of users are getting this error, for both Outlook and Exchange, and the general conclusion is that Microsoft is to blame. This issue usually happens with Outlook 2016 but can happen with other versions as well. The message will lead you to believe that you need to update information in your profile, which is impossible to do since Outlook refuses to open and you can’t do anything with it. However, there are a few things that you can do, such as modifying the registry or creating an .xml file that takes care of the issues with autodiscover. Read on to see what you can do about this issue.

Method 1: Use the /resetnavpane command

The resetnavpane switch clears and regenerates the Navigation Pane for the current user profile. It also removes all favorite folders and shortcuts, and does the same thing that deleting profilename.xml would do. Note that there is a space between “Outlook.exe” and “/resetnavpane”. This should help you fix the issue with Outlook and you can continue using it again.

Method 2: Delete the keys within the Profiles of Outlook, via the Registry Editor

Deleting a certain folder from the Registry Editor will cause Outlook to start repopulating the OST data. The OST data is used when you have an exchange account, and you want to use the Cached Exchange Mode or you simply want to work offline. Afterwards, you can continue using Outlook as usual. You can even attach a PST as well, which is used for IMAP, POP3 and web-based mail accounts, if you want or need. HKEY_CURRENT_USER\SOFTWARE\Microsoft\Office\16.0\Outlook\Profiles\Outlook

Method 3: Tell Outlook not to respond to AutoDiscover, but your domain instead

The issue in question happens because the root domain server responds to the autodiscover request, and Outlook doesn’t even make it to AutoDiscover.[domain.com]. If you add the registry entry below, you are telling Outlook to ignore the root domain, and go to the next option on the list.

Option 1: Via Registry Editor

Option 2: Via an .xml file

Method 4: Delete your profile and create a new one

This is the last resort, as it completely deletes your Outlook profile, and you have to create a new one, and reconfigure your connection. Even though, the steps are listed below but if you would like a picture guide, then view (here). When you’re done, you will have created the account/profile again, only this time configured the way Windows likes it, and you won’t have any issues with it. At the end of the day, this, along with a number of other issues, happens due to the fact that Microsoft constantly upgrades and evolves Windows, and not all new functionalities are compatible with their older counterparts. However, if you simply follow any of the methods above, you will have your Outlook account running again in no time.

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